Preexposure Prophylaxis Uptake Among Spanish-Speaking Transgender Women: A Randomized Controlled Trial in North and South Carolina, 2019–2022. By: Rhodes, Scott D.; Alonzo, Jorge; Mann-Jackson, Lilli; Aviles, Lucero Refugio; Tanner, Amanda E.; Galindo, Carla A.; Bessler, Patricia A.; Courtenay-Quirk, Cari; Garcia, Manuel; Sucaldito, Ana D.; Smart, Benjamin D.; Goldenberg, Tamar and Reboussin, Beth A. 2024. American Journal of Public Health. Vol. 114 Issue 1, p68-78.

Objectives. To evaluate Chicas Creando Acceso a la Salud (Girls Creating Access to Health; ChiCAS), a Spanish-language, small-group intervention designed to increase preexposure prophylaxis (PrEP) use, consistent condom use, and medically supervised gender-affirming hormone therapy use among Spanish-speaking transgender Latinas who have sex with men. Methods. Participants were 144 HIV-negative Spanish-speaking transgender Latinas, aged 18 to 59 years, living in North and South Carolina. From July 2019 to July 2021, we screened, recruited, and randomized them to the 2-session ChiCAS intervention or the delayed-intervention waitlist control. Participants completed assessments at baseline and 6-month follow-up. Follow-up retention was 94.4%. Results. At follow-up, relative to control participants, ChiCAS participants reported increased PrEP use (adjusted odds ratio [AOR] = 4.64; 95% confidence interval [CI] = 1.57, 13.7; P <.006). However, ChiCAS participants did not report increased use of condoms or medically supervised gender-affirming hormone therapy. ChiCAS participants reported increases in knowledge of HIV (P <.001), sexually transmitted infections (P <.001), and gender-affirming hormone therapy (P =.01); PrEP awareness (P <.001), knowledge (P <.001), and readiness (P <.001); condom use skills (P <.001); and community attachment (P <.001). Conclusions. The ChiCAS intervention was efficacious in increasing PrEP use among Spanish-speaking, transgender Latinas in this trial. (Am J Public Health. 2024;114(1):6878.